Isopropyl isocyanate is an organic compound that belongs to the isocyanate group. Isocyanates is an important class of intermediates that belong to a family of compounds commonly known as heterocumulenes. The chemistry of these compounds is characterized by nucleophilic addition and cycloaddition reaction modes. Other common names of isopropyl isocyanate are propane, 2-isocyanato, 2-isocyanatopropane, and methyl ethyl isocyanate. Isopropyl isocyanate is a colorless liquid and it possesses strong pungent odor.
The molecular formula of isopropyl isocyanate is (CH3)2CHNCO and its molecular weight is 85.11. A major route for the industrial production of isopropyl isocyanate is through the reaction of N-propan-2-ylcarbamoyl chloride with 2, 4, 6-trichlorophenol, which offers the product yield of around 88%. Isopropyl isocyanate is incompatible with several groups of chemical compounds and it reacts exothermally, releasing noxious gases.
Isopropyl isocyanate is principally used as an intermediate for the manufacture of several industrial chemicals in industries such as fertilizers, pharmaceutical, and chemical. It is used as a reagent in the synthesis of O-aryl N-isopropyl carbamates. The compound is also used as a reagent in the manufacture of the androgen receptor antagonist used for treating prostate cancer. It is also used as a derivatization reagent in the stereo-isomeric analysis of secondary alcohols. Isopropyl isocyanate is employed to synthesize the selective dual inhibitor of mammalian target of rapamycin 1 and 2 (mTORC1 and mTORC2). Isopropyl isocyanate is toxic.
It can cause skin irritation and is fatal if inhaled. Reactions of this compound with alkali metals, aldehydes, mercaptans, phenols, alcohols, amines, ketones, peroxides, strong oxidizers, or hydrides result in the release of extreme heat. These reactions can occur with explosive violence. Increasingly stringent regulations regarding the use of toxic chemicals across the world are anticipated to restrain the growth of the isopropyl isocyanate market during the forecast period.
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